Authors: Goto M, Yamazaki S, Kato Y, Yamamoto K, Katagata Y Abstract Proteoglycans comprise a family of complex macromolecules consisting of a core protein with covalently attached glycosaminoglycan (GAG) chains. The skin anti-aging effects of oral administration of proteoglycan fractions with different molecular weights from salmon nasal cartilage were investigated in a hairless mouse model of skin aging; aging was caused by repeated ultraviolet B (UVB) irradiation. Three proteoglycan fractions of different molecular weights were prepared from salmon nasal cartilage water extract by ion-exchange column chromatography and gel filtration column chromatography
DESCRIPTION OF RIOUXGOLVANIA KAPAPKAMUI SP. N. (NEMATODA: MUSPICEOIDEA: MUSPICEIDAE), A PECULIAR INTRADERMAL PARASITE OF BATS IN HOKKAIDO, JAPAN
Authors: Kitano T, Yoda H, Tabata K, Miura M, Toriyama M, Motohashi S, Suzuki T Abstract We investigated the cytotoxicity of eight vitamin K3 (VK3) analogs against neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, and SK-N-SH) and normal cell lines (human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)) using a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay.
Authors: Neerincx A, Rodriguez GM, Steimle V, Kufer TA Abstract Nucleotide-binding domain and leucine-rich repeat (NLR) proteins play important roles in innate immune responses as pattern-recognition receptors. Although most NLR proteins act in cell autonomous immune pathways, some do not function as classical pattern-recognition receptors. One such NLR protein is the MHC class II transactivator, the master regulator of MHC class II gene transcription.
Authors: Mu H, Calderone TL, Davies MA, Prieto V, Wang H, Mills GB, Bar-Eli M, Gershenwald JE Abstract The bioactive phospholipid lysophosphatidic acid (LPA) and its receptors LPA(1-3) are aberrantly expressed in many types of human cancer. LPA has been reported to induce tumor cell proliferation, migration, and cytokine production.
Authors: Ansurudeen I, Sunkari VG, Grünler J, Peters V, Schmitt CP, Catrina SB, Brismar K, Forsberg EA Abstract Diabetes mellitus (DM) is a progressive disorder with severe late complications. Normal wound healing involves a series of complex and well-orchestrated molecular events dictated by multiple factors. In diabetes, wound healing is grossly impaired due to defective, and dysregulated cellular and molecular events at all phases of wound healing resulting in chronic wounds that fail to heal
Authors: Pistone G, Doukaki S, Rizzo D, Aricò M, Bongiorno MR Abstract Acquired bilateral nevus of Ota-like macules (ABNOM) or nevus of Hori is a circumscribed dermal melanocytoses characterized by blue-brown mottled hyperpigmentation occurring bilaterally on the forehead, temples, eyelids, nose, with a predilection of malar areas; multiple sites may be involved(1) (fig.1a). Clinically it could be hard to distinguish from the congenital bilateral nevus of Ota (type IV nevus of Ota).(2) We herein report seven cases of ABNOM, periodically evaluated at the Dermatological Department of University of Palermo from April 2004 to June 2010. The purpose of the present study is to define the in vivo histologic features of ABNOM and to elucidate its pathogenesis.
Authors: van de Kamp J, Kramann R, Anraths J, Schöler HR, Ko K, Knüchel R, Zenke M, Neuss S, Schneider RK Abstract For tissue engineering, cultivation of pluripotent stem cells on three-dimensional scaffolds allows the generation of organ-like structures. Previously, we have established an organotypic culture system of skin to induce epidermal differentiation in adult stem cells.
Authors: Yoshioka D, Ishii H, Uchida T, Fujiwara S, Umeki K, Sakamoto N, Kadota J Abstract Bullous pemphigoid, the most common autoimmune blistering disease, is characterized by an autoimmune response to a component of hemidesmosomes within the dermal-epidermal junction. Immunofluorescence examination of skin biopsies demonstrates linear deposition of IgG and C3 in the basement membrane zone
This article is part of a Special Issue entitled Lactoferrin and has undergone the Journal’s usual peer review process. Biochem Cell Biol
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